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KMID : 0614620220800040190
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Korean Journal of Gastroenterology
2022 Volume.80 No. 4 p.190 ~ p.194
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Gastric CD56-negative Extranodal Natural Killer/T-cell Lymphoma: A Case Report
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Chung Joo-Hong
Jee Sam-Ryong
Choi Eun-Jeong
Yu Seung-Jung
Yoon Jun-Sik
Lee Hong-Sub
Lee Sang-Heon
Park Sung-Jae
Park Ha-Young
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Abstract
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Extranodal natural killer (NK)/T-cell lymphoma, nasal type (ENKTCL-NT) is the most common subtype of Epstein-Barr virus-associated NK/T-cell lymphomas. ENKTCL-NT occurs infrequently in the gastrointestinal tract. In particular, reports of ENKTCL-on NT arising from the stomach are extremely rare. Several clusters of differentiation (CDs) have been useful in recognizing NK-cells, T-cells, and tumor cells of NK/T-cell lymphomas. Among them, the CD56 antigen is considered the most sensitive marker for ENKTCL-NT and is expressed in almost all cases of ENKTCL-NT. Thus, the development of CD56-negative ENKTCL-NT is highly atypical. This paper reports a case of a young Asian female who presented with gastric ulcer bleeding. The patient was histologically diagnosed with ENKTCL-NT. No tumor cells for CD56 were observed, whereas no monoclonality of the T-cell receptor gamma gene rearrangement was detected in the tumor cells. The patient was scheduled for systemic chemotherapy six times and achieved complete remission. Peripheral blood-hematopoietic stem cell transplantation was performed later.
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KEYWORD
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Lymphoma, extranodal NK-T-cell, Stomach ulcer, CD56 antigen, T-lymphocytes
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